somascan^® discovery

reproducible

Because the SomaScan Assay does not rely on polyclonal antibodies, which are variable, SomaScan

data achieves coefficients of variation much lower than industry standards. Additionally, it is the only platform

that can be seamlessly used for the entire biomarker research pipeline from discovery to development consistently over time.

SPECIFICITY

While most protein assays rely on a variation of the ELISA sandwich approach, the SomaScan Assay relies on kinetics: non-specific interactions dissociate faster. Tests have confirmed minimal cross-reactivity with closely related proteins.

DYNAMIC RANGE

A tiered dilution approach is used to measure proteins of very high abundance and very low abundance separately, such that a total range of 10 logs can be measured from just 55 μl of plasma or serum.

MENU SIZE

The largest commercial proteomic assay on the market,

providing over 7,000 protein measurements.

Breakdown of proteins on the SomaScan® Assay for which biological pathways are

known (chart generated via the PANTHER classification system http://pantherdb.org/)

SENSITIVITY

The tiered approach used for SomaScan measurements enables the

detection of very rare proteins consistently without sample pre-treatment.