Most protein assays excel in one or two areas
The somascan® platform is fundamentally different
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REPRODUCIBLE
x̴5% CV
REPRODUCIBLE
Because the SomaScan Assay does not rely on polyclonal antibodies, which are variable, SomaScan data achieves coefficients...
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SPECIFIC
extensively characterized
SPECIFIC
While most protein assays rely on a variation of the ELISA sandwich approach, the SomaScan assay relies...
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DYNAMIC
x10 log range
DYNAMIC
Each SOMAmer reagent averages a 4.7 log dynamic range, but a tiered dilution approach is used to measure proteins...
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x
SENSITIVE
125 fM
SENSITIVE
The tiered approach used for SomaScan measurements enables detection of very rare proteins consistently without sample pre-treatment...
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LARGEST MENU
x7,000 analytes
LARGEST MENU
By far the largest commercial proteomic assay on the market, the SomaScan assay provides over 7,000 unique protein measurements...
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HIGH THROUGHPUT
x680 samples/day
ULTRA HTP
Our workflow is massively multiplexed using a scalable system of robotics. Today, we can assay 680 clinical samples per day...
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A single platform for discovery, validation, and delivery
The SomaScan® Assay uses Slow Off-Rate Modified Aptamers (called SOMAmer® reagents) to provide 7,000 highly reproducible measurements of circulating proteins from a single sample of plasma, serum, or urine.
UNIQUE REAGENTS
SOMAmer reagents are synthetic, ssDNA sequences with protein-like appendages that tightly bind a specific protein target
DEVELOPED BY SELEX
Precise requirements for binding and durability are controlled via a directed evolution process called SELEX
FOR DISCOVERY, VALIDATION, & delivery
Unlike antibodies, SOMAmer reagents are eternally consistent, enabling unmatched reproducibility
How does the somascan assay work?
SomaScan outperforms antibody and mass-spec based proteomic approaches
We are using all major proteomics approaches including antibody-based and MS-based methods in addition to SomaScan because of their complementarity. SomaScan stands out, however, with the largest coverage of plasma proteome, no sensitivity limitation, excellent reproducibility/precision, and impressive throughput.
✔ Validated
key somalogic publications
SEMINAL SOMASCAN
PUBLICATION
Introduces the SomaScan Assay and demonstrates how chemically modified aptamers can be used to detect and discover biomarkers.
improving selex with modified aptamers
Describes how additional functional groups were used to increase the diversity of aptamers in the SELEX process, expanding to 3,000 targets.
SOMAMER REAGENT
CRYSTAL STRUCTURE
Reports the crystal structure of a SOMAmer reagent binding PDGF-BB. Unlike traditional aptamers, the SOMAmer reagent utilizes hydrophobic interactions and mimics the natural receptor.
